SMTP transient error

Can anyone point me to a possible resolution on this. IBM believes it’s a network error, but doesn’t give any specifics. The I.P.'s listed are our mailrelay spam server. All external email goes through it before being delivered to the outside world. External mail will start backing up and external mail will stop routing.

01/29/2007 08:56:15 AM Router: No messages transferred to XXX.XX.XX.X1; XXX.XX.XX.X2 (host XXX.XX.XX.X1) via SMTP: SMTP Protocol Returned a Transient Error

IBM says that the mail relay host field in the configuration doc should be listed as such:

XXX.XX.XX.X1; XXX.XX.XX.X2

Thank you