Internet surfing slows down

Some users have the problem, that internet surfing slows down after a while. I deleted perweb.nsf but after some hours the problem returned. When the client is terminated and started again, surfing is normal for some hours. Then it slows down again and opening a webpage needs some minutes.

We use Notes 6.0.2CF2 and Domino 6.5.4FP2 and Internet Explorer integration.