550 requested action not taken: mailbox unavailable or not local

Hi,i have some problem with the email server.All my customer send to us the email, there are very high posibility that they receive the error.

550 requested action not taken: mailbox unavailable or not local

Sometimes we can receive the mails. But the customer required to resend probably a few times.

And also when we send mail, there are times that the mail at stuck in the server.

I didn’t make any changes to the server and previously it was running fine. Please advise what is the problem and how to solve as soon as possible.