550 #5.1.0 Address Is Rejected Error

Looking for help with this error. I have two Domino servers that send mail out to the internet via SMTP, and I want to route all mail through and IronPort device that’s been added to the network. When I add in the address of the IronPort to the messaging configuration doc, in the “Relay host for messages leaving the local internet domain field”, I get a delivery failure with the error that’s in the subject line (550 #5.1.0 Address is Rejected). We also have an Exchange server on the network that can supposedly relay mail through the IronPort device, so I’m not sure if it’s Domino that’s kicking back the error and it’s not even getting to the IronPort, or if the error is coming back because the IronPort is rejecting the messages. Any ideas? When I look at the mail routing events, I see the Domino server try to transfer the messages to the ip of the IronPort, but then it comes back with the error message. Thanks in advance for any help.

Subject: 550 #5.1.0 Address Is Rejected Error

my guess would be the irnport appliance is rejecting it. the person who administers the ironport device should be able to tell you why and will likely need to add your domino servers to a white list of some sort.