Server cluster

I have clustered server on R6.5.5.

Mail quota is set during user registration.

Home server = Cluster1

Cluster1 mail DB has 100MB.

Cluster2 mail DB has 8GB.

I want to implement “clrepl_obeys_quotas=1”.

Question : which db size will take precedent? so that I must make plenty of allowance if the cluster take cluster2 size. Also what is the best practise to implement this ini variable? Thanks.