Think I understand what you mean. My terminology might be a fraction out, but…
You may have a bunch of Domino servers, but you have a dedicated SMTP server, but it’s getting hammered, and you would like some sort of fail over.
We have serverA and ServerB both have SMTP enabled, both can send out to the internet, and both can recieve SMTP. So if either server goes down, email is still sent externally. For inbound, the MX record has 2 delivery addresses, which you can load balance or set for failover (we have actually set 1 to be the primary, and only send to serverB on failure of serverA).
Now we have a set up where if either of our SMTP servers go down, email will be routed out and in. We have quite a vanilla set up, serverA and serverB are clustered mail servers, so user automatically fail over, but if you have a stack of mail servers which forward mail to SMTP server(s), in the configuration above, I read a great article a while back, pretty sure if you search for cluster AND SMTP in this forum you will find it, which explains how to set up connection docs, but using groups (containing clustered servers) instead of named servers and the delivery will be forwarded to your SMTP servers, regardless if one is down.