Domino Server Gateway Configuration

All of the Domino servers here are behind the firewall with a SendMail server in the DMZ passing all Internet email to and from the Internet. Now that we are getting ready to implement 6.0.1 here, my management has asked to remove the Sendmail server and use a Domino server in it’s place. I am curious what different types of configurations are commonly used, and what is the preferred configuration? What problems have occurred with the configurations?