Domino Back/Restore is a flexible framework for native Domino backup.
The dominobackup.nsf plays an important role for backup and restore operation.
It contains the following type of content.
Backup/restore/prune configuration
Inventory documents for restore operations
Restore requests
Backup logs
You could run backup with different excludes defined on command-line.
Or just backup selected databases or incremental backups.
But there cannot be different active configurations nor different backup retention in one dominobackup.nsf
This is a companion discussion topic for the original entry at https://blog.nashcom.de/nashcomblog.nsf/dx/domino-backuprestore-with-multiple-configurations-and-targets.htm