We are running (3) 64 bit Domino 8.5 servers on a win 2003 server. Would like to run on a 2008 server whenever support is available for it. Maybe a Lotusphere anouncement?
We run in VMWare Server and ESX but not 64-bit nor with 4GB RAM… sorry. Not had issues with 512MB to 2.5GB 32-bit 8.5.
It is stated in this for Win2k8 64 bit :
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IBM Lotus Notes and Domino 8.5 expands platform capabilities with the addition of support for platforms such as AIX 64 bit, Windows 2008 64 bit, Citrix 64 bit, Ubuntu 8.0.4, and Macintosh OS X 10.5 (Leopard).